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What effect does menopause have on osteoclast cells?

  1. Decreased activity

  2. Increased activity

  3. No effect

  4. Irregular activity

The correct answer is: Increased activity

Menopause leads to hormonal changes, specifically a decrease in estrogen levels. Estrogen plays a significant role in regulating bone metabolism, including the activity of osteoclasts, which are the cells responsible for bone resorption. With lower estrogen levels post-menopause, there is an increase in osteoclast activity. This heightened activity contributes to an imbalance in bone remodeling, where bone resorption surpasses bone formation, ultimately leading to a decline in bone density. This state can increase the risk of osteoporosis and fractures in postmenopausal women. Thus, understanding the correlation between menopause and osteoclast activity is crucial for managing bone health in this population.